Mice that have lost their Y chromosome but continue their lineage could save humanity from extinction

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Mice that have lost their Y chromosome but continue their lineage could save humanity from extinction

A male-determining gene on the Y chromosome determines the sex of human and other mammalian newborns. However, the human Y chromosome is degenerating and may go extinct in a few million years unless humans discover a new sex gene.

The good news is that two rodent species have already lost their Y chromosome and survived.

A new study published in the Proceedings of the National Academy of Sciences demonstrates how the spiny rat evolved a new male-determining gene.

The Y chromosome’s role in determining human sex

Females, like other animals, have two X chromosomes, whereas men have a single X plus a teeny little chromosome called Y. The names have nothing to do with their form; the X represented “unknown.”

The X comprises around 900 genes that perform a variety of functions unrelated to sex. However, the Y has just approximately 55 genes and a lot of non-coding DNA – basic repeating DNA that appears to accomplish nothing.

The Y chromosome, on the other hand, delivers a powerful punch because it carries a crucial gene that initiates masculine development in the embryo. Around 12 weeks after conception, this master gene activates others that govern testicular growth. Male hormones (testosterone and its derivatives) are produced by the embryonic testis, ensuring that the newborn develops as a boy.

SRY (sex region on the Y) was the name given to this master sex gene in 1990. It operates by activating a genetic pathway that begins with the SOX9 gene.

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The disappearing Y

Most mammals have an X and Y chromosome similar to ours; an X with lots of genes, and a Y with SRY plus a few others. This system comes with problems because of the unequal dosage of X genes in males and females.

How did such a weird system evolve? The surprising finding is that Australia’s platypus has completely different sex chromosomes, more like those of birds.

In platypus, the XY pair is just an ordinary chromosome, with two equal members. This suggests the mammal X and Y were an ordinary pair of chromosomes not that long ago.

In turn, this must mean the Y chromosome has lost 900–55 active genes over the 166 million years that humans and platypus have been evolving separately. That’s a loss of about five genes per million years. At this rate, the last 55 genes will be gone in 11 million years.

Our claim of the imminent demise of the human Y created a furore, and to this day there are claims and counterclaims about the expected lifetime of our Y chromosome – estimates between infinity and a few thousand years

Mice that have lost their Y chromosome but continue their lineage could save humanity from extinction 1
The Amami spiny rat (Tokudaia osimensis) is endemic to the Japanese island of Amami Ōshima. Asato Kuroiwa

Rodents with no Y chromosome

The good news is we know of two rodent lineages that have already lost their Y chromosome – and are still surviving.

The mole voles of eastern Europe and the spiny rats of Japan each boast some species in which the Y chromosome, and SRY, have completely disappeared. The X chromosome remains, in a single or double dose in both sex.

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Although it’s not yet clear how the mole voles determine sex without the SRY gene, a team led by Hokkaido University biologist Asato Kuroiwa has had more luck with the spiny rat – a group of three species on different Japanese islands, all endangered.

Kuroiwa’s team discovered most of the genes on the Y of spiny rats had been relocated to other chromosomes. But she found no sign of SRY, nor the gene that substitutes for it.

Now at last they have published a successful identification in PNAS. The team found sequences that were in the genomes of males but not females, then refined these and tested for the sequence on every individual rat.

What they discovered was a tiny difference near the key sex gene SOX9, on chromosome 3 of the spiny rat. A small duplication (only 17,000 base pairs out of more than 3 billion) was present in all males and no females.

They suggest this small bit of duplicated DNA contains the switch that normally turns on SOX9 in response to SRY. When they introduced this duplication into mice, they found that it boosts SOX9 activity, so the change could allow SOX9 to work without SRY.

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What this means for the future of men

The imminent – evolutionarily speaking – disappearance of the human Y chromosome has elicited speculation about our future.

Some lizards and snakes are female-only species and can make eggs out of their own genes via what’s known as parthenogenesis. But this can’t happen in humans or other mammals because we have at least 30 crucial “imprinted” genes that work only if they come from the father via sperm.

To reproduce, we need sperm and we need men, meaning that the end of the Y chromosome could herald the extinction of the human race.

The new finding supports an alternative possibility – that humans can evolve a new sex determining gene. Phew!

However, evolution of a new sex determining gene comes with risks. What if more than one new system evolves in different parts of the world?

A “war” of the sex genes could lead to the separation of new species, which is exactly what has happened with mole voles and spiny rats.

So, if someone visited Earth in 11 million years, they might find no humans – or several different human species, kept apart by their different sex determination systems.

resource utilized: https://theconversation.com/

 

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