According to a police statement, a fire broke out at 03.50 local time at the nursing home in the town of Bedburg-Hau with a population of 13,000.
One of the firefighters who arrived at the scene and started extinguishing the fire was injured and hospitalized.
Teams evacuated 46 people from the nursing home. According to the first determinations, 4 people lost their lives and 23 people were injured in the incident.
The fire has been extinguished to a large extent, cooling processes and investigations into the cause of the fire are ongoing.