New hope against aging: water bears

The findings also show that tardigrade proteins can be used to stabilize pharmaceutical products

2 mins read
New hope against aging: water bears

Scientists have discovered that tardigrade proteins can slow down the metabolism in human cells, a development that could one day lead to technologies that slow down the aging process.

Tardigrades, or water bears, are one of the world’s most indestructible life forms and are capable of surviving in extreme conditions.

They can survive being completely dried, frozen, heated above 150 degrees Celsius, exposed to light several thousand times beyond what a human can withstand, and even in the vacuum of space.

Previous studies have shown that these creatures, which are less than half a millimeter long, can enter a vegetative state to protect their bodies when exposed to extreme conditions.

Scientists sought to find out what mechanisms tardigrades use to enter and exit this temporary death state when faced with environmental stresses.

Now a team of researchers led by the University of Wyoming (UW) in the US has found that water bears use gel-forming proteins inside their cells to slow down their life processes.

They discovered that when these proteins are added to human cells, the molecules gel, just like in tardigrades, and slow down metabolism.

The researchers also found that when human cells producing these tardigrade proteins were put into a state of temporary death, the cells became more resistant to stresses.

This process, which gives human cells some of the skills of water bears, was also found to be reversible.

“When the stress is removed, the tardigrade gels dissolve and the human cells return to their normal metabolism,” said study co-author Thomas Boothby of the UW.

Previous research has shown that an important drug used to treat patients with hemophilia can be stabilized by different types of tardigrade proteins.

The latest finding could lead to the development of new technologies focused on inducing a state of transient death in cells and even whole organisms to slow down aging.

The finding also provides additional evidence that proteins from tardigrades could be used to deliver life-saving treatments to people where refrigeration is not possible, and to increase the storage potential of therapies such as stem cells.

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